Lectures on MR - Diffusion weighted MR Spectroscopy

Society/Institution: ESMRMB
Date: 10.10.2018 - 12.10.2018
Venue: ICM - Institut du Cerveau et de la Moelle épinière; Hôpital Pitié-Salpêtrière
City: Paris
Country: France
Language(s): English
Main Topic: MR Spectroscopy
Expected number of participants: less than 50
Description: This course is designed to provide a strong practical foundation in the principles of diffusion weighted magnetic resonance spectroscopy (DW-MRS) in all of its aspects. DW-MRS provides unique cell-specific microstructural information based on the diffusion properties of intracellular metabolites in neural and muscle tissue, and it thus complements most sensitive but less specific methods such as diffusion tensor imaging (DTI). In clinical and preclinical research, incorporation of DW-MRS in a comprehensive protocol aimed at microstructural characterisation of tissue allows disentangling the effect of multiple pathological processes on tissue microstructure, and thus significantly increases the explanatory power of MR for the overall pathology. At present, however, incorporation of DW-MRS in standard protocols poses significant challenges: robust DW-MRS sequences are not offered on any of the commercially available MR scanners. DW-MRS data acquisition is highly susceptible to physiological fluctuations, and the DW-MRS signal is strongly affected by e.g. eddy currents generated by the strong diffusion weighting gradients and cardiac pulsation. As a result, the robustness and reproducibility of DW-MRS strongly depends on a highly specialized pipeline of acquisition and processing that takes into account as many possible adverse effects as possible.
Website: www.esmrmb.org
Email: office@esmrmb.org
Category: Lectures on MR
for MR physicists and other basic or clinical scientists

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